Answer: There are two factors that determine the urine flow rate during an osmotic diuresis: the rate of excretion of effective osmoles in the urine and the effective osmolality of the interstitial compartment of the renal medulla.
The normal range for 24-hour urine volume is 800 to 2,000 milliliters per day (with a normal fluid intake of about 2 liters per day).
